Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.

Status: Recruiting
Location: See all (13) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: f
View:

• Have a high risk primary colorectal malignancy

• Have a negative CT or includes no confirmatory evidence of liver metastases

• Is able to undergo treatment if liver metastasis is found

• Have provided written informed consent to participate in the study

• Be aged 16 years or over

Locations
Other Locations
United Kingdom
Royal Bolton Hospital
RECRUITING
Bolton
Queen's Hospital
NOT_YET_RECRUITING
Burton-on-trent
Broomfield Hospital
RECRUITING
Chelmsford
Medway Maritime Hospital
RECRUITING
Gillingham
Royal Liverpool Hospital
RECRUITING
Liverpool
Macclesfield District General Hospital
RECRUITING
Macclesfield
Royal Gwent Hospital
RECRUITING
Newport
George Eliot Hospital
RECRUITING
Nuneaton
Queen Alexandra Hospital
RECRUITING
Portsmouth
Salisbury District Hospital
RECRUITING
Salisbury
Royal Stoke University Hospital
RECRUITING
Stoke-on-trent
Royal Marsden Hospital
RECRUITING
Sutton
University Hospital of South Manchester & Manchester Royal Infirmary
RECRUITING
Wythenshawe
Contact Information
Primary
Caroline Martin
c.martin1@imperial.ac.uk
+44 (0) 7749 655 817
Backup
Syvella Ellis
giclinicaltrials@imperial.ac.uk
+44 (0) 7732 315 234
Time Frame
Start Date: 2014-08
Estimated Completion Date: 2031-12
Participants
Target number of participants: 282
Treatments
Experimental: Diffusion Weighted MRI scan
Patients who are enrolled in the study will undergo an additional diffusion weighted MRI (T2W, DWI and ADC sequences) of the liver.
Authors
Gina Brown
Related Therapeutic Areas
Sponsors
Collaborators: Pelican Cancer Foundation
Leads: Imperial College London

This content was sourced from clinicaltrials.gov